Interactions of Dopamine D1 and N-methyl-D-Aspartate Receptors are Required for Acute Cocaine-Evoked Nitric Oxide Efflux in the Dorsal Striatum

Alterations in nitric oxide (NO) release in response to psychostimulants in the striatum cause a plastic change contributing to the development and expression of addiction. In this study, regulation of NO efflux evoked by acute cocaine in the dorsal striatum was investigated using real-time detection of NO in vivo. We found that acute systemic injection of cocaine (20 mg/kg) increased NO efflux, which was reduced by the intrastriatal infusion of the dopamine D1 receptor antagonist, SCH23390 (7.5 nmol), and the dopamine D2 receptor agonist, quinpirole (5 nmol). Increased levels of NO efflux by acute cocaine were also reduced by the intrastriatal infusion of the N-methyl-D-aspartate (NMDA) receptor antagonists, MK801 (2 nmol) and AP5 (2 nmol). These findings suggest that interactions of dopamine D1 receptors and NMDA receptors after acute exposure to cocaine participate in the upregulation of NO efflux in the dorsal striatum.

The effect of respiratory protection with biological monitoring on the health promotion of lead workers / 대한산업의학회지

No abstract available.

Interelationship Between Axial Length and Refractive States, and Anterior Chamber Depth in the Newborn

The aims of the our study are investigation of the average value of the refraction, anterior chamber depth(ACD), axial length(AL), and the interrelationship of refraction, ACD, AL, weight and height of normal newborn infant. Objects of this study are 236 eyes of 118 normal newborn infants that have been examined with retinoscope under the cycloplegia and the axial length and anterior chamber depth have been measured by ultrasonogram. And so we gained following results. The average value of refraction(+1.85 +/- 1.86D), the average value of the AL(17.5 +/- 0.68mm) and the average value of ACD(2.62 +/- 0.21mm) did not show significant difference between male and female newborn infants. The correlation coefficient between AL and ACD. refraction and AL, weight and AL, and height and AL were 0.326(P0.1).

Refraction by Photo refraction

Photorefraction was performed in 96 cases(191 eyes) after instillation of tropicamide and cyclopentolate for the purpose of screening procedure. And then refraction was also carried out by retinoscope. From this comparison study, phtorefraction provided data which were very close to those obtained from the conventional retinoscopy.

A Case of Anterior Lenticonus in Alport's Syndrome

Alport's syndrome, first described by Alport in 1927, is a clinical entity which consists of lens abnormalities, hereditary hemorrhagic nephritis and nerve deafness. Anterior lenticonus is a rare structual anomaly of lens in which there is a conicalor spherical protrusion of the anterior lens surface into the anterior chamber as a characteristic finding of Alport's syndrome. The authers experienced a case of Alport's syndrome in a 22-year-old man associated with bilateral anterior and posterior lenticonus, hematuria, proteinuria, renal failur earld nerve deafness(complete form).

A Case of Sympathetic Ophthalmia

Sympathetic ophthalmia is a rare, diffuse, granulomatous inflammation of the entire uvea, usually bilateral, which occurs days, months, or years after penetrating ocular injury or intraocular surgery. This presented case was a 34 years old male patient injured his left eye suspecting a scleral laceration. The exciting eye(left) was eviscerated 8 days after injury and sympathetic eye(right) was developed sympathetic ophthalmia 8 weeks after injury. A brief review of the related literatures is presented.

The Study on The Near Point in Koreans

The near point of accommodation of 500 normal Koreans aged 8 to 70 was measured for the monocular and binocular states. Push-up method with Slataper's one-two line card was used. Calculation for the near:point was measured by Prince rule with AD phoropter. The results were divided into 15 age groups as follows; 1. The age group of 8 to 11 ; The range:of monocular accommodative power was 17.2D. to 12.3D. The mean value was 15.2D. The range of binocular accommodative power was 19.2D. to 14.2D. The mean value was 17.4D. The excess of binocular accommodative power was 2.2D. 2. The age group of 12 to 15 ; The range of monocular accommodative power was 15.2D. to 10.4D. The mean value was 13.8D. The range of binocular accommodative power was 18.8D. to 13.9D. The mean value was 15.4D. The excess of binocular accommodative power was 1.6D. 3. The age group of 16 to 19 ; The range of monocular acocmmodative power was 14.8D. to 9.8D. The mean value was 12.3D. The range of binocular accommodative power was 17.6D. to 12.4D. The mean value was 13.7D. The eXcess of binocular accommodative power was 1.4D. 4. The age group of 20 to 23 ; The range of monocular accommodative power was 13.4D. to 8.8D. The mean value was 11.2D. The range of binocular accommodative power was 15.9D. to 10.8D. The mean value was 12.6D. The excess of binocular accommodative power was 1.4D. 5. The age group of 24 to 27 ; The range of monocular accommodative power was 12.8D. to 8.0D. The mean value was 10.4D. The range of binocular accommodative power was 13.7D. to 9.2D. The mean value was 11.8D. The excess of binocular accommodative power was 1.4D. 6. The age group of 28 to 31 ; The range of monocular accommodative power was 12.0D. to 7.4D. The mean value was 9.5D. The range of binocular accommodative power was 12.8D. to 8.6D. The mean value was 10.8D. The excess of binocular accommodative power was 1.3D. 7. The age group of 32 to 35 ; The range of monocular accommodative power was 11.4D. to 6.6D. The mean value was 8.8D. The range of binocular accommodative power was 11.9D. to 7.9D. The mean value was 10.0D. The excess of binocular accommodative power was 1.2D. 8. The age group of 36 to 39 ; The range of monocular accommodative power was 10.2D. to 5.3D. The mean value was 7.2D. The range of binocular accommodative power was 11.2D. to 6.8D. The mean value was 8.4D. The excess of binocular accommodative power was 1.2D. 9. The age group of 40 to 43 ; The range of monocular accommodative power was 8.2D. to 3.8D. The mean value was 5.4D. The range of binocular accommodative power was 9.7D. to 5.0D. The mean value was 6.4D. The excess of binocular accommodative power was 1.0D. 10. The age group of 44 to 47 ; The range of monocular accommodative power was 7.8D. to 2.3D. The mean value was 4.1D. The range of binocular accommodative power was 9.1D. to 3.4D. The mean value was 4.9D. The excess of binocular accommodative power was 0.8D. 11. The age group of 48 to 51 ; The range of monocular accommodative power was 4.0D. to 1.2D. The mean value was 2.0D. The range of binocular accommodative power was 6.2D. to 1.6D. The mean value was 2.8D. The excess of binocular accommodative power was 0.8D. 12. The age group of 52 to 55 ; The range of monocular accmmodative power was 2.7D. to 0.9D. The mean value was 1.8D. The ranie of binocular accommodative power was 4.3D. to 1.0D. The mean valae was 2.0D. The excess of binocular accommodative power was 0.5D. 13. The age group of 56 to 59 ; The range of monocular accomIllodative power was 1.8D. to 0.7D. The mean value was 1.0D. The range of binocular accommodative power was 2.8D. to 0.7D. The mean value was 1.5D. The excess of binocular accommodative power was 0.5D. 14. The age group of 60 to 63 ; The range of monocular accommodative power was 1.2D. to 0.4D. The mean value was 0.7D. The range of binocular accommodative power was 1.8D. to 0.5D. The mean value was 1.0D. The excess of binocular accommodative power was 0.3D. 15. The age group of 64 to 70 ; The range of monocular accommodative power was 1.0D. to 0.2D. The mean value was 0.6D. The range of binocular accommodative power was 1.6D. to 0.4D. The mean value was 0.8D. The excess of binocular accommodative power was 0.2D. The human ocular occommodative power was decreased according to the increasing age. The binocular accommodative power was larger than the monocular accommodative power. The excess between binocular and monocular accommodative power was also decreased according to the increasing age. In all age group, the mean excess between binocular and monocular accommodative power was about 1.0 diopter that was more or less larger than the Duane's. In the age group of 50 years below, these values were larger than the Duane's. In the age group of 50 years above, these values were similar to the Duane's.

Two Cases of Familial Exudative Vitreoretinopathy

The vitreoretinopathy with familial tendency was first described by V.G.Criswick and C.L. Schepens in 1969. The disease is slowly progressive and can be clinically grouped into 3 stages according to the severity of ocular manifestation. The etiology of this disease which is similar to the other vitreoretinopathy without the history of prematurity and oxygen supply is unknown. Two sibling patients suggesting to have the familial exudative vitreoretinopathy were reported and reviewed herein with their clinical features.

A Human case of thelaziasis in Korea

The authors recovered a white thread-like living nematode in left conjunctival sac of a 33 years old male on May 29, 1981. The chief complaints were foreign body sensation and itching sensation of eye. The worm was a female measuring 12.1 mm in length and 0.171 mm in maximum width. It was identified as Thelazia callipaeda Railliet et Henry, 1910. And we recorded the patient as the 10th reported thelaziasis case in Korea.

A Case of Congenital Optic Pit

Optic pits are congenital craterlike holes or indentation in the surface of the optic disc. They are oval in shape and located in the inferior temporal quadrant of the optic disc. The authors experienced a case of congenital optic pit of the left eye of 18 year old male-patient. Fluorescein angiography showed hypofluorescence of the pit in early arteriovenous phase, becomming hyperfluorescence in the late phase. Ophthalmoscopic view of the diseased eye showed no abnormality of macular area. There was no visual field defect except the enlarged physiologic blind spot. Here we briefly report a case of congenital optic pit. referring the literature relating to the optic pit.